PEGylated protein drugs: basic science and clinical applications

PEGylation technology and key applications are introduced by this topical volume. Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improvedPK/PD, and decreased immunogenicity, are discussed. Furthermore, chemical andenzymatic strategies for the coupling and the conjugate characterization are reported. Following chapters describe approved and marketed PEG-proteins and PEG-oligonucleotides as well as conjugates in various stages of clinical development. The volume closes with chapters on FDA regulations and EMEA guidelines for these drugs and general perspectives for future developments Vast information on PEG and PEG-conjugates collected in one book Competent authorship from academia and industry assures comprehensive information INDICE: From the contents PEG properties as related to pharmacokinetics and immunogenicity of protein conjugates.- Protein-polymer conjugates: synthesis.- Protein conjugates purification and characterization.- PEG and PEG conjugates toxicity.- G-CSF site specific amino conjugation.- Site specific disulphide conjugation: new PEG protein products.- Growth hormone PEGylation: strategies and properties.- Certulizumag Pegol, an anti TNF antibody.- Uricase PEGylation and potential applications.- Therapeutic properties of differently PEGylated interferons as related to their structure.- New therapeutically useful PEG conjugates based on TGase mediated conjugation: the G-CSF case.- Small molecules PEGylation: results and prospective.- Peptide and oligonucleotide PEGylation: approved drugs and products in development.- Guidelines for polymer-conjugates approval for marketing.

• ISBN: 978-3-7643-8678-8
• Editorial: Birkhaüser
• Encuadernacion: Cartoné
• Páginas: 250
• Fecha Publicación: 01/01/2009
• Nº Volúmenes: 1
• Idioma: Inglés