Since their discovery, Wnt signaling molecules have been shown to control keyevents in embryogenesis, to maintain tissue homeostasis in the adult and, when aberrantly activated, to promote human degenerative diseases and cancer, thus making them a vital area of study.á Wnt Signaling: Methods and Protocolsáexamines both biochemical assays and vertebrate and invertebrate model systems toprovide a point of reference to current molecular protocols and the diverse model systems employed to study this important signaling pathway.á In Volume 2,Pathway Models,áthe diverse vertebrate and invertebrate models that have shaped the Wnt signaling field are described,ápresenting an overview of the uniqueproperties of each organism, like asymmetric cell division in C. elegansáand epithelial morphogenesis in Dictyostelium,áwith respect to studying Wnt/FZD function.á As a volume in the highly successful Methods in Molecular Biology™ series, chapters contain readily reproducibleálaboratory protocols, complete with lists of necessary equipment and reagents and the Notes section, whichárevealsáhelpful troubleshooting tips. Comprehensive and cutting-edge, Wnt Signaling: Methods and Protocols collects the expertise and knowledge of many leaders in the field to produce this invaluable two-volume resource.
- ISBN: 978-1-61737-899-7
- Editorial: Springer
- Encuadernacion: Rústica
- Páginas: 498
- Fecha Publicación: 01/01/2009
- Nº Volúmenes: 1
- Idioma: Inglés