Developing Therapeutics for Alzheimers Disease: Progress and Challenges

Developing Therapeutics for Alzheimer's Disease: Progress and Challenges provides a thorough overview of the latest advances toward the development of therapeutics for Alzheimer's disease, along with the major hurdles that still must be overcome and potential solutions to these problems. Despite the lack of progress toward developing therapeutics that can slow or stop the progression of this disease, important discoveries have been made and many promising approaches are advancing in preclinical studies and clinical trials. This book outlines the special challenges related to specific targets and approaches, while presenting a realistic, comprehensive and balanced view of drug discovery and development in this area. Written by international leaders in the field, the book assesses prospects for the emergence of effective agents and allows readers to better understand the challenges, failures, and future potential for research in Alzheimer's disease. This book is a valuable resource to academic scientists carrying out translational research in Alzheimer's disease, industrial scientists engaged in Alzheimer's drug discovery, executives in biopharmaceutical companies making strategic decisions regarding the direction of internal research and potential outside partnerships, and graduate-level students pursuing courses on Alzheimer's therapeutics. Provides a realistic but promising assessment of the potential of various therapeutic approaches to Alzheimer's diseaseFocuses primarily on neuroprotective agents and cognitive enhances, as well as approaches to targeting the amyloid ß-peptide, tau and Apolipoprotein EDiscusses alternative approaches, preclinical and clinical development issues, related biomarkers and diagnostics, and prevention and nonpharmacological approachesFeatures input from international leaders in the field INDICE: 1. The Complex Pathways to Mechanism-Based Therapeutics in Alzheimer's Disease2. The Genetic Basis of Alzheimer's Disease3. B-Secretase Inhibition4. Y-Secretase Inhibitors: from Chemical Probes to Drug Development5. Therapeutic Targeting of AB426. Modulators of Amyloid B-Protein (AB) Self-Assembly7. Anti-Amyloid-B Immunotherapy for Alzheimer's Disease8. Targeting AB Receptors to Modify Alzheimer's Disease Progression9. Blood-Brain Barrier Transport of Alzheimer's Amyloid B-Peptide10. Alzheimer's Disease Therapeutics Targeting Apolipoprotein E11. Microtubule Stabilization12. Tau Phosphorylation as a Therapeutic Target in Alzheimer's Disease13. Stimulation of Tau Degradation 14. Passive Immunotherapy for Tau Pathology15. Inhibition of Tau Aggregation as a Basis for Treatment and Prevention of Alzheimer's Disease 16. Neuroprotective Strategies for Alzheimer's Disease Prevention and Therapy17. Symptomatic Cognitive Enhancing Agents18. Tackling Alzheimer's Disease by Targeting Oxidative Stress and Mitochondria19. Preclinical and Clinical Issues in Alzheimer Drug Development 20. Molecular Imaging in Alzheimer Clinical Trials21. Fluid Biomarkers and Diagnostics 22. Non-Pharmacologic Activity Interventions to Prevent Alzheimer's Disease23. Prospects and Challenges for Alzheimer Therapeutics

• ISBN: 978-0-12-802173-6
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 672
• Fecha Publicación: 01/06/2016
• Nº Volúmenes: 1
• Idioma: Inglés