Epigenetic Regulation in Overcoming Chemo-Resistance explains how epigenetic agents can enhance the chemotherapy sensitivity of diverse types of cancers. It provides a comprehensive delineation and the recent development of the scientific studies on the epigenetic regulation in enhancing chemo-sensitivity. The book discusses several topics such as DNA methyltransferase inhibitors (DNMTi), Histone deacetylases inhibitors (HDACi), Histone lysine demethylases inhibitors (HDMi), Histone lysine methyltransferases inhibitors (HMTi) and drugs regulating the microRNA, long non-coding RNA (lncRNA) or RNA methylation. Additionally, it discusses recent and future developments of the field of epigenetic regulation. The book is a valuable resource for cancer researchers, clinicians, graduate students and several members of biomedical field who are interested in learning about epigenetic regulation methods to reverse chemo-resistance in cancers. Presents detailed diagrams of the mechanisms of epigenetic regulation for easy consultEncompasses multiple clinical trial summary diagrams to help readers get the information from clinical trials quickly and clearlyProvides future perspectives in each section to inspire readers to use epigenetic regulation to overcome chemo-resistance INDICE: 1. The role of epigenetic regulation in cancer 2. DNA methyltransferase inhibitors (DNMTi) as sensitizing agents to overcome chemo-resistance 3. Histone deacetylases inhibitors (HDACi) as sensitizing agents to overcome chemo-resistance 4. Histone lysine demethylases inhibitors (HDMi) as sensitizing agents to overcome chemo-resistance 5. Histone lysine methyltransferases inhibitors (HMTi) as sensitizing agents to overcome chemo-resistance 6. Drugs regulating the microRNA to overcome chemo-resistance 7. Drugs regulating the lncRNA to overcome chemo-resistance 8. Drugs regulating the mRNA methylation to overcome chemo-resistance 9. Future combined epigenetic therapy
- ISBN: 978-0-12-823684-0
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 360
- Fecha Publicación: 01/02/2021
- Nº Volúmenes: 1
- Idioma: Inglés