Pharmacology and Toxicology of Cytochrome P450 - 60th Anniversary

This volume highlights the extensive contributions by worldwide researchers in the cytochrome P450 (P450) field over past six decades since the first article on P450 was published in 1962. Research on many forms of P450s has been extended into different fields, from molecules to in vivo situations, because pharmacologists and toxicologists appreciate and are attracted to the potential therapeutics. The purpose of this volume was to collect a comprehensive description of major progress to date, to discuss the possible future directions, and to invite young researchers to join this important and exciting world of P450. Comprehensive coverage of major progress in the last 60 years on the P450 research in pharmacology and toxicology Discussion of possible future directions of the research on P450s, especially for improved pharmacotherapy in humans Encouragement to young scientists to join this important and exciting basic, translational, and advanced world of P450 INDICE: Preface Hiroshi Yamazaki 1. Multiple conformations of cytochromes P450 & the relevance to predicting SAR F. Peter Guengerich 2. Pharmacogenetics of the cytochromes P450 and relevance to drug metabolism Ann Daly 3. Cytochromes P450 drug metabolism within the brain Rachel F. Tyndale 4. Mammalian cytochrome P450 biodiversity: Physiological importance, function, and protein and genomic structures of cytochromes P4502B in multiple species of woodrats with different dietary preferences M. Denise Dearing 5. Atypical kinetics of cytochrome P450 enzymes in drug metabolism Eric Chun Yong Chan 6. Biosynthesis using cytochrome P450 Enzymes: focus on synthesis of drug metabolites W. Griffith Humphreys 7. Use of engineered cytochrome P450s for accelerating drug discovery and development Elizabeth Gillam 8. Assessing cytochrome P450 function using genetically engineered mouse models Xinxin Ding 9. Use of the biologicals with sustainable reproducibility for phenotyping study of cytochrome P450 enzymes involved in the biotransformation of test compounds and calculating the fraction unbound parameter, for anticipating drug Interactions Christophe Chesné 10. Cytochromes P450 in chimeric mice with humanized liver Shotaro Uehara 11. Polymorphic cytochromes P450 in non-human primates Yasuhiro Uno 12. Cytochromes P450 in pediatrics (and elder people) Chie Emoto 13. Pre-emptive cytochromes P450 genotyping for better pharmacotherapy Magnus Ingelman-Sundberg

• ISBN: 978-0-323-91109-2
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 312
• Fecha Publicación: 01/08/2022
• Nº Volúmenes: 1
• Idioma: Inglés