Modern molecular biology: approaches for unbiased discovery in cancer research

Molecular biology has rapidly advanced since the discovery of the basic flow of information in life, from DNA to RNA to proteins. While there are several important and interesting exceptions to this general flow of information, the importance of these biological macromolecules in dictating the phenotypic nature of living creatures in health and disease is paramount. In the last one and a half decades, and particularly after the completion of the Human Genome Project, there has been an explosion of technologies that allow the broad characterization of these macromolecules in physiology, and the perturbations to thesemacromolecules that occur in diseases such as cancer. In this volume, we willexplore the modern approaches used to characterize these macromolecules in anunbiased, systematic way. Such technologies are rapidly advancing our knowledge of the coordinated and complicated changes that occur during carcinogenesis, and are providing vital information that, when correctly interpreted by biostatistical/bioinformatics analyses, can be exploited for the prevention, diagnosis, and treatment of human cancers. The purpose of this volume is to providean overview of modern molecular biological approaches to unbiased discovery in cancer research. Advances in molecular biology allowing unbiased analysis ofchanges in cancer initiation and progression will be overviewed. These include the strategies employed in modern genomics, gene expression analysis, and proteomics. The purpose of this volume is to provide an overview of modern molecular biological approaches to unbiased discovery in cancer research Advances in molecular biology allowing unbiased analysis of changes in cancer initiationand progression will be overviewed These include the strategies employed in modern genomics, gene expression analysis, and proteomics INDICE: Genome sequencing.- Examining copy number changes.- Genomic sequence variation.- DNA protein interactions.- DNA methylation changes.- SAGE and other signal sequencing technologies.- Gene expression microarray technologies.- RNA interference and regulatory RNAs.- Protein microarrays.- Mass Spectrometry in proteomics.

• ISBN: 978-0-387-69744-4
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 300
• Fecha Publicación: 29/08/2010
• Nº Volúmenes: 1
• Idioma: Inglés