Bioactive Lipid Mediators in Cardiopulmonary Pharmacology

Bioactive lipid mediators are derived from the metabolism of N-3 and N-6 polyunsaturated fatty acids (PUFAs) by cyclooxygenases (COXs), lipooxygenases (LOXs) and cytochrome P450 monooxygenases (CYPs). These mediators are involved in a vast array of signaling pathways that regulate both physiological and pathophysiological responses. There is significant interest in developing new therapies that modulate the production and elimination of these metabolites which have been shown to play a role in a variety of diseases of the heart and lung. This volume offers unique insights into how these bioactive lipid mediators regulate homeostasis with a focus on the respiratory and cardiovascular systems, and reviews recent work on the development of novel therapeutics that target these critical cellular pathways. Provides reviews from world experts in the field of bioactive lipid mediators Each chapter focuses on current topics with an emphasis on development of novel therapeutics The issue covers a diverse range of bioactive lipids derived from COX, LOX or CYP-mediated metabolism of omega-3 and omega-6 PUFAs INDICE: Preface Darryl Zeldin and John Seubert 1. Cyclooxygenases and Vascular Function Jane Mitchell 2. Cyclooxygenases and Platlet Function Paola Patrignani 3. Eicosanoids and Cardiomyopathies Dao Wang 4. Cytochrome P450 Bioactive Lipids in the Heart Rheem Totah 5. Epoxide Hydrolase and Leukotoxin in the Heart and Lung Bruce Hammock 6. Role of cytochrome P450-epoxygenase and soluble epoxide hydrolase in the regulation of vascular response Mohammed A. Nayeem 7. Bioactive Lipids in Hypertension John Imig 8. Cytochrome P450 Metabolites and Angiogenesis Ingrid Fleming 9. 20-Hydroxyeicosatetraenoic Acid and Vascular Function Victor Garcia 10. Cytochrome P450 Eicosanoids and the Brain Nabil Alkayed 11. Omega-3 Oxylipids Wolf-Hagen Schunck 12. Resolvins, Lipoxins and Inflammation Matthew Spite 13. Endocannabinoids as Bioactive Metabolites Aditi Das 14. Oxylipins and Aspirin Exaccerbated Respiratory Disease Elina Jerschow

• ISBN: 978-0-323-95057-2
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 312
• Fecha Publicación: 01/06/2023
• Nº Volúmenes: 1
• Idioma: Inglés